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| Powder: | Yes |
| Customized: | Customized |
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Product Name:Exenatide CAS:196078-30-5 Mf:C173h273n51o56s2 EINECS No.:203-067-6 Molecular Weight:3951.41000 Color:White Use:Chemical and Pharmaceutical Intermediates Quality:Top Type:Pharmaceutical Intermediates Shelf Life:2 Years When Properly Stored Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. |
Pramlintide acetate is an injectable human amylin analog that has been launched for the treatment of both type 1 and type 2 diabetes. While it is also a 37-amino acid peptide, it differs from its parent predecessor by the substitution of Ala-25, Ser-28, and Ser-29 with prolines. Not only do these modifications improve the solubility of the peptide, they also eliminate the aggregation observed with amylin, resulting in a stable synthetic analog with retention of biological activity that is suitable for pharmaceutical use.
As an indication of potency, Pramlintide acetate inhibits the binding of radioiodinated rat amylin to rat nucleus accumbens membranes with a Ki value of 23 pM.
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