| Powder: | Yes |
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| Customized: | Customized |
| Certification: | GMP, HSE, ISO 9001, USP, BP |
| Suitable for: | Elderly, Children, Adult |
| State: | Powder |
| Purity: | >99% |
| Samples: |
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| Customization: |
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Product Name:PNC-27 Peptide Cas No: 67727-97-3 MW:4113.57754 Appearance: white powder Customized:Customized Quality:Refined Type:Pharmaceutical Intermediates Shelf Life:2 Years When Properly Stored Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. |
The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53
and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by inducing
membranolysis. We find that our previously determined 3D structure of the p53 residues of PNC-27 is directly
superimposable on the structure for the same residues bound to HDM-2, suggesting that the peptide may target
HDM-2 in the membranes of cancer cells.
We now find significant levels of HDM-2 in the membranes of a varietyof cancer cells but not in the membranes of
several untransformed cell lines. In colocalization experiments, we find that PNC-27 binds to cell membrane-bound
HDM-2. We further transfected a plasmid expressing full-length HDM-2 with a membrane-localization signal into
untransformed MCF-10-2A cells not susceptible to PNC-27 and found that these cells expressing full-length HDM-2
on their cell surface became susceptible to PNC-27. We conclude that PNC-27 targets HDM-2 in the membranes of
cancer cells, allowing it to induce membranolysis of these cells selectively.
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8. We has manyyears' exporting experience in active pharmaceutical ingredient products.,Strictly on selecting raw materials.
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