| Customization: | Available |
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| Varieties: | Growth Promoting Medicine |
| Component: | Animal |
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High Purity Veterinary Insecticide Raw Powder CAS 70288-86-7 Ivermectin
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effectively, but for adult worms; For only in intestinal fecal round worms are also effective.
1. Ivermectin is the derivatives of abamectin. Ivermectin belongs to semisynthetic broad-spectrum resistant parasites.
2. Ivermectin has effect for most of the various life cycle nematodes.
3. Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.
4. Ivermectin has effect for dung round worms that is only stay in intestinal tract.
5. Ivermectin has selective inhibition.
6. Ivermectin can not go through the blood brain barrier of humanbeings.
In veterinary medicine ivermectin powder is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage.
It is sometimes administered in combination with other medications to treat a broad spectrum of animal parasites. Some dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and the Australian Shepherd), though, have a high incidence of a certain mutation within the MDR1 gene (coding for P-glycoprotein); affected animals are particularly sensitive to the toxic effects of ivermectin.
Clinical evidence suggests kittens are susceptible to ivermectin toxicity. A 0.01% ivermectin topical preparation for treating ear mites in cats (Acarexx) is available.
Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated.
| Tests | Specification | Results | |
| Appearance | White or yellowish-white crystalline powder, slightly hygroscopic. | Yellowish-white crystalline powder, slight hygroscopic. | |
| Solubility | Practically insoluble in water, soluble in alcohol. | Qualified | |
| Identification | IR | Corresponds to that of CRS standard | Qualified |
| HPLC | The retention time for H2Bla and H2Blb in the chromatogram obtained with the test solution corresponds to those of standard preparation | Qualified | |
| Appearance of solution | Clear and not more intensely colored than BY? | Clear | |
| Specific optical rotation (anhydrous and solvent-free substance), ° | -20--17 | -17.9 | |
| Related substances (%) | Individual impurity(RRT 1.3-1.5)≤2.5 | I-l:<0.05 K:2.1 | |
| Any other impurity ≤ 1 | C:0.06 A:0.57 J:0.14 H:0.39 D:<0.05 F:<0.05 E:0.36 1-2:0.19 |
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| Total ≤5 | 3.8 | ||
| Disregard limit: 0.05 | |||
| Ethanol and Formamide (%) | Ethanol ≤5.0 | 3.9 | |
| Formamide≤3.0 | 2.5 | ||
| Catalyst (ug/g) | ≤1 | <1 | |
| Water (%) | ≤1.0 | 0.26 | |
| Sulphated ash (%) | ≤0.1 | 0.07 | |
| Heavy Metal (%) | ≤0.002 | <0.002 | |
| Assay (%) (HPLC, on dry basis) | H2Bla/(H2Bla +H2Blb)≥90.0 | 97.7 | |
| 95.0≤H2Bla +H2Blb≤ 102.0 | 96.7 | ||
| Conclusion | Complies with the requirements of EP10.0 | ||
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